The Incidence of Adrenal Cortical Carcinoma in Gonadectomized Female Mice of the Extreme Dilution Strain

Gonadectomized mice of the ce strain are of interest because they have a high incidence of adrenal cortical carcinomas (2). These tumors are extremely rare in normal mice, as evidenced by observations at the Jackson Memorial Laboratory and by the infrequent references to such growths in the literature. Adrenal cortical carcinomas are themselves of special interest because of evidence that they are the source of internal secretions of the nature of sex hormones (3). This is a report of observations on ovariectomized and intact ce female mice from 13 to 24 months of age. In earlier reports ovariectomized mice of this strain up to 1 year of age were discussed.